Search results for "Tetanic stimulation"

showing 3 items of 3 documents

Anticonvulsants do not suppress long-term potentiation (LTP) in the rat hippocampus

1991

Long-term potentiation (LTP) of population spikes in the CA1 area of rat hippocampus was induced by tetanic stimulation of stratum radiatum in slices kept submerged in a perfusion chamber. Addition of the two antiepileptic drugs phenytoin or the diazepine midazolam to the medium did not significantly alter this phenomenon within 22 min after the tetanus. The early enhancement (post-tetanic potentiation, PTP) was reduced only by phenytoin. Therefore an interaction of these drugs with N-methyl-D-aspartate (NMDA) receptors and LTP induction is unlikely.

MaleMidazolammedicine.medical_treatmentPopulationHippocampusIn Vitro TechniquesPharmacologyNeurotransmissionHippocampusLTP inductionmedicineAnimalseducationEvoked Potentialsgamma-Aminobutyric Acideducation.field_of_studyChemistryGeneral NeuroscienceRats Inbred StrainsLong-term potentiationRatsAnticonvulsantnervous systemPhenytoinSynapsesNMDA receptorAnticonvulsantsFemaleTetanic stimulationNeuroscience Letters
researchProduct

Growth hormone potentiates thyroid hormone effects on post-exercise phosphocreatine recovery in skeletal muscle.

2012

International audience; OBJECTIVE: The aim of the study was to determine the respective impact of thyroxine and growth hormone on in vivo skeletal mitochondrial function assessed via post exercise phosphocreatine recovery. DESIGN: The hind leg muscles of 32 hypophysectomized rats were investigated using (31)P nuclear magnetic resonance spectroscopy at rest and during the recovery period following a non tetanic stimulation of the sciatic nerve. Each rat was supplemented with hydrocortisone and was randomly assigned to one of the 4 groups: the group Hx was maintained in hypopituitarism., the group HxT was treated with 1 μg/100g/day of thyroxine (T4), the group HxG with 0.2 IU/kg/day of recomb…

MalePhosphocreatineThyroid hormonesEndocrinology Diabetes and MetabolismMESH: Random AllocationThyroid GlandSkeletal muscleHypopituitarismMESH: Physical Conditioning AnimalMESH: Drug SynergismNuclear magnetic resonancechemistry.chemical_compoundRandom Allocation0302 clinical medicineEndocrinologyMESH: Human Growth HormoneMESH: AnimalsMESH : Muscle Skeletal0303 health sciencesMESH: Muscle Skeletal[ INFO.INFO-IM ] Computer Science [cs]/Medical ImagingMESH : RatsHuman Growth HormoneThyroidDrug Synergismmedicine.anatomical_structuremedicine.drugmedicine.medical_specialtyMESH : Drug SynergismMESH: RatsMESH : MaleSomatotropin030209 endocrinology & metabolismMESH: PhosphocreatinePhosphocreatineMESH : Random Allocation03 medical and health sciencesIn vivoInternal medicine[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyPhysical Conditioning AnimalMESH : Thyroxinemedicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingAnimalsHumansMESH : PhosphocreatineMESH : Human Growth HormoneMitochondrionMESH : Physical Conditioning AnimalMuscle Skeletal030304 developmental biologyHydrocortisoneMESH: HumansMESH : HumansSkeletal muscleMESH : Thyroid GlandMESH: Thyroxinemedicine.diseaseMESH: MaleMESH: Thyroid GlandRatsThyroxineEndocrinologychemistryRatMESH : AnimalsTetanic stimulation[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyHormoneGrowth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
researchProduct

Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4

2001

Neurotrophin-4 (NT-4) is produced by slow muscle fibers in an activity-dependent manner and promotes growth and remodeling of adult motorneuron innervation. However, both muscle fibers and motor neurons express NT-4 receptors, suggesting bidirectional NT-4 signaling at the neuromuscular junction. Mice lacking NT-4 displayed enlarged and fragmented neuromuscular junctions with disassembled postsynaptic acetylcholine receptor (AChR) clusters, reduced AChR binding, and acetylcholinesterase activity. Electromyographic responses, posttetanic potentiation, and action potential amplitude were also significantly reduced in muscle fibers from NT-4 knock-out mice. Slow-twitch soleus muscles from thes…

End-plate potentialNeuromuscular JunctionElectromyographyBiologyNeuromuscular junctionCellular and Molecular NeuroscienceMicePostsynaptic potentialmedicineAnimalsReceptors CholinergicNerve Growth FactorsMuscle SkeletalMolecular BiologyAcetylcholine receptorMice KnockoutMotor Neuronsmedicine.diagnostic_testMuscle fatigueElectromyographyAge FactorsLong-term potentiationneuromuscular junction; neurotrophin-4; synaptic transmissionCell Biologymedicine.anatomical_structureMuscle Fibers Slow-TwitchMuscle FatigueAcetylcholinesteraseTetanic stimulationNeuroscienceMuscle Contraction
researchProduct